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Background and Aims Now in Ukraine there are 70 000 military patients with the amputations. If first-line drugs are ineffective, it becomes necessary to use second-line opioids for a long time, which can lead to serious side effects One of the innovative approaches in the treatment of chronic neuropathic pain is the use of specialized interventions in the form of injections of botulinumtoxin A ( BoNT-A), which is due to its unique mechanism of action, namely blocking cholinergic transmission in neuromuscular synapses, which leads to inhibition of acetylcholine release.Methods A group of patients (21 soldiers),3 months after an injury to the upper or lower extremities requiring different levels of amputation suffered from post-amputation pain without somatic comorbidity and received injections of incoBoNT-A- 100–200 units.There are the following methods of injection: into the neuroma, into the triger point, subcutaneously. The target is to diagnose a neuroma using an ultrasound. The injection of Incobotulinum neurotoxin A is performed under the navigation control of an ultrasound, using a linear sensor (frequency 5–15 MHz), in-plane or out-of-plane method of visualisation, depending on the depth of the neuromaResults Statictics 42 patients were injected BoNT- A, treatment results devided into 3 groups (depending on the treatment method), the greatest effect of pain reduced - decreased from 7,7 until 3,6 points on the scale of VAS resulted from the combination of BoNT-A + physical therapy + and antidepressant + anticonvulsant. Efect was stable and lasted for 3 monthsConclusions Following the selection of patients with available treatment outcomes, analysis across three treatment groups—categorized by therapeutic approach— demonstrated that the combination of incoBoNT-A, physical therapy (PT), and an antidepressant plus anticonvulsant resulted in the most significant reduction in pain. Pain scores decreased from 7.7 to 3.6 on the Visual Analogue Scale (VAS),with the effect remaining stable over a period of three months.