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Background and Importance Eco-responsible healthcare practice is one that, while maintaining equal quality and patient safety, has a reduced impact on the environment. Owing to their high environmental footprint, operating rooms are a key area for sustainability interventions.Aim and Objectives In this context, the pharmacy is tasked with reviewing the composition of surgical kits no longer aligned with current practices. This work is carried out with consideration for the three pillars of sustainable development: environmental, economic, and social.Material and Methods This project is conducted by a pharmacist and an intern, in collaboration with medical and paramedical teams. Optimal kit compositions are developed and submitted to suppliers. Trials are organised to validate the proposed modifications. Environmental impact is assessed by measuring the amount of waste avoided: unused and discarded medical devices (MDs), and the packaging of ‘satellite’ MDs. To evaluate economic impact, the new kits’ prices are compared with current costs, including the prices of the previously referenced kits and the ‘satellite’ MDs. Finally, users receive a satisfaction survey.Results Nine surgical kits were revised. The VASCULAR kit required the most changes, with 10 references to be removed and 10 new ones added. The environmental impact is estimated at 2.2 tonnes of waste avoided annually, including 800 kg from the CARDIAC kit due to optimised drapes. Annual savings of 45000€ are estimated. Savings from multiple kits help fund more expensive kits, as a safer CAESAREAN kit. Analysis of the surveys shows 96% (96/100) satisfaction. Numerous exchanges with healthcare providers confirm a positive social impact: time savings, reduced musculoskeletal disorders, and improved safety. However, some limitations appeared: difficulty in standardising practices, storage issues and supply chain disruptions.Conclusion and Relevance Beyond positive ecological impact, the revision of surgical kits offers numerous benefits: enhanced safety, time savings and cost reduction. However, some limitations have emerged and need to be considered.The project is strongly supported by our institution’s Sustainable Development Steering Committee. Through this initiative, evaluation of additional kits has begun as preparation for the next tender process.Conflict of Interest No conflict of interest