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Background Spinocerebellar ataxia type 27B (SCA27B) is a recently characterised cause of individuals presenting with late onset cerebellar ataxia. It is a rare autosomal dominant neurodegenerative disorder caused by mutations in the Fibroblast Growth Factor 14 (FGF14) gene. Here, we present a case of late onset cerebellar ataxia with associated Parkinsonism that is responsive to levodopa.Case A 65 year-old female presents with a progressive deterioration in her gait secondary to truncal ataxia since the age of 62 years. Throughout the course of her illness, she developed asymmetrical parkinsonism, bowel and bladder incontinence, and had a background of parasomnias preceding her presentation and also a family history of late onset parkinsonism and early onset cognitive impairment. Brain magnetic resonance imaging revealed atrophy of the midbrain, PONS, and middle cerebellar peduncles. Genetic testing confirmed a pathogenic triplet repeat within the FGF14 gene consistent with a diagnosis of SCA27B. Levodopa was commenced for her parkinsonism, with improvement in the speed and amplitude of her movements, and restoration of partial independence. On discharge, fampridine was introduced to support continued functional restoration.Conclusion SCA27B should be considered in individuals presenting with late onset ataxia, and may mimic alternate neurodegenerative conditions. This case report demonstrates that associated parkinsonism may be responsive to levodopa.