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Introduction Intestinal failure (IF) is a rare disease whereby the gut cannot absorb sufficient nutrients and/or fluids. Treatment is with intravenous support via a central venous catheter, termed home parenteral nutrition (HPN). Complications of long-term HPN include catheter related bloodstream infections (CRBSI), intestinal failure associated liver disease (IFALD) and line related thrombosis. NHS England and BAPEN (British Association of Parenteral and Enteral Nutrition) reports have described an increase in HPN prevalence in recent years. This is the first study to characterise the experience of our HPN centre.Methods Patients were identified through a retrospective audit of current and historical records of those who had been under the care of the nutrition team for home parenteral nutrition. Patient notes (electronic and paper) and scripts were reviewed and data entered onto an excel database for analysis.Results 810 records were identified, 104 patients were excluded as not being discharged on home PN leaving 706 records. Patients were then primarily classified into existing patients (n=195), deceased (n=330) and discharged (n=172). 551 of patients were classified as benign and 155 classed as palliative.The most common underlying diagnosis in benign patients was surgical complications, followed by Crohn’s disease. The most common mechanism of IF was short bowel syndrome.New registrations on HPN in the unit over time are displayed in figure 1. There was a 158% increase in new palliative patients between 2014 and 2020.Mean days on HPN for benign patients were 1699. Mean days on HPN for palliative patients was 279.Data for deceased benign patients (n=184) showed 73.4% (n=136) died of non-IF related causes, 7.7% (n=14) were attributed to CRBSI, 0.5% (n=1) to IFALD, and 15.8% (n=29) were missing cause of death data.For discharged patients the most common reason for cessation of HPN was restoration of continuity surgery (47.1%), followed by clinical improvement (33.1%) and other surgery (11.6%).Conclusions Surgical complications and Crohn’s disease were the most common causes of intestinal failure in this cohort. The number of HPN registrations increased rapidly between 2000 and 2020 but rate of growth has slowed. The majority of HPN patients died from non-intestinal failure related causes. A small but important percentage of mortality was attributed to CRBSI– highlighting the importance of scrupulous central venous catheter care.Abstract P376 Figure 1