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The spread of syphilis through Europe at the end of the 15th century is well documented, as is the use of mercury as a treatment. Less commonly discussed are the botanical remedies that were also used in an attempt to alleviate the symptoms or cure the disease. Some of these were used for over 200 years, before their use declined as the ‘Theory of Humours’ fell out of favour and the teachings of Paracelsus took greater hold. While guaiacum features most frequently in literature of the time, a number of other botanicals were also widely used, whether on their own, combined with other herbs or in conjunction with mercury preparations. 1 2