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Please confirm that an ethics committee approval has been applied for or granted: Yes: I’m uploading the Ethics Committee Approval as a PDF file with this abstract submissionApplication for ESRA Abstract Prizes : I apply as an Anesthesiologist (Aged 35 years old or less)Background and Aims Chronic postoperative pain is a common complication following breast surgery and significantly impacts patients‘ quality of life. A network meta-analysis has shown that regional techniques—such as paravertebral nerve block (PVB), pectoral nerve-2 block (PECS II), serratus anterior plane block (SAP block), erector spinae plane block (ESPB), rhomboid intercostal block, and local anesthetic infusion—provide significant relief from acute postoperative pain. However, data on their effectiveness in preventing chronic pain remain limited. This retrospective study aims to evaluate whether multimodal analgesia (MMA) can effectively reduce the incidence of chronic postoperative pain, providing new evidence to guide clinical pain management.Methods This single-center retrospective study extracted data from the hospital’s electronic medical record system, selecting records from October 1, 2023, to October 31, 2024. The study included adult patients who underwent breast surgery, with or without multimodal analgesia (MMA). MMA consisted of intravenous acetaminophen, opioids, NSAIDs, and nerve blocks (PECS I, PECS II, SAP, and PIFB). Postoperative pain was assessed using the Visual Analogue Scale (VAS) three to six months after surgery and analyzed using the Chi-square test.Results A total of 103 patients who underwent breast surgery were included in the study, with 14 receiving MMA and 89 not receiving MMA. The proportion of patients without chronic postoperative pain was 71.4% in the MMA group and 64.0% in the non-MMA group. Chi-square test results showed a statistically significant difference (p = 0.027, < 0.05) ( table 1). These findings suggest that patients who received MMA had a significantly lower incidence of chronic postoperative pain compared to those who did not.Abstract P047 Table 1The comparison of chronic pain between multimodal analgesia group (MMA) group and non-MMA groupConclusions Our study suggests that multimodal analgesia (MMA) significantly reduces the likelihood of chronic pain in patients undergoing breast surgery.