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Background and Importance Managing ancillary supplies (AS) involves a risk-based approach to select, qualify and track these supplies to ensure they are safe for the preparation and administration of an investigational product (IP).Incompatibility of AS used in Phase I clinical trials (CTs), which focus on the safety and dosage of a new treatment, can affect the reliability of the data, patient safety and the validity of the CTs themselves.It is crucial to select the appropriate AS that meet the requirements of the trial pharmacy manual and the sponsor, taking into account the priority of using the centre’s local AS.Aim and Objectives Identify ongoing CTs in a Phase I Unit that require AS for the preparation and administration of an IP.Check whether there are restrictions or not with the Unit’s AS, according to the CT requirements.Analyse the causes of not being able to use local AS and the sponsor’s solution.Material and Methods Observational, retrospective study, including ongoing CTs at 01 Oct 2025 with IPs that require parenteral route (iv, sc, it…).Main data collected were type of AS (diluent bags, syringes, secondary sets, filters, administration sets and closed system transference devices for preparation and administration (CSTDs), permitted or non-permitted use of local AS and causes.Data source: preparation sheets.Results 108 CTs were identified.In 30% of them, the use of any local AS is not permitted; of which 90% are not allowed in at least two types of AS. Regarding the type of AS not permitted in relation to the CTs identified:– CSTDs for preparation (22,2%): 54,2% (sponsor supplied a tested reference) and 45,8% (sponsor did not allow their use).– Administration sets (13,9%): 53,3% (sponsor supplied a tested reference) and 46,7% (sponsor allowed to use a local compatible alternative).– CSTDs for administration (11,1%): sponsor supplied a tested reference in 100%.– Filters (8,3%), secondary sets (6%), diluent bags (4,6%) and syringes (1,9%).Conclusion and Relevance The high variability of AS, local or provided by sponsor, can lead a risk of mistakes due to use of incorrect AS, worker unsafety, lack of knowledge of how to use them, less storage space, and a greater complexity of the CT.For later phases/commercialisation, the restriction on AS can be a limiting factor.Therefore, sponsors should conduct as extensive testing of references and materials as possible in the early stages.Conflict of Interest No conflict of interest