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Epstein-Barr virus (EBV) is a common virus that causes paediatric rhabdomyolysis. Acute compartment syndrome is a rare complication of rhabdomyolysis that can lead to severe consequences. We report the case of a previously healthy boy in early childhood with EBV-associated rhabdomyolysis complicated by acute compartment syndrome that required decompressive fasciotomy. The patient recovered without loss of strength, sensation or range of motion. This case report aims to focus attention on serious complications such as acute compartment syndrome that can occur with common viruses.