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Background and Aims Peripheral nerve blocks are effective for surgical anesthesia and multimodal analgesia. Intravenous lipid emulsion (ILE), used to treat local anesthetic toxicity, may shorten block duration. This study compared the effects of intravenous ILE and normal saline on motor block duration in rats with percutaneous sciatic nerve block.Methods This randomized, double-blind study was conducted at Ondokuz Mayıs University Experimental Animals Center with 20 male Wistar Albino rats undergoing unilateral sciatic nerve block. Rats were randomized into two groups: ILE (Group L) received 7.5 ml/kg 20% lipid emulsion IV, and normal saline (Group S) received 7.5 ml/kg IV. Motor, sensory, and deep sensory block durations were assessed by a blinded researcher at multiple time points until full recovery. The primary outcome was motor block recovery time; secondary outcomes were sensory and deep sensory recovery times.Results Twenty male Wistar Albino rats (average weight 355 g) with normal motor activity were included (Group S:10, Group L:10). The mean motor recovery time after sciatic nerve block was 94 ± 6.9 minutes in Group S and 36 ± 8.4 minutes in Group L, showing a significant difference (P < 0.05). Sensory block duration was 104 ± 5.1 minutes for Group S and 45 ± 9.7 minutes for Group L, while deep sensory block lasted 104 ± 11.7 minutes in Group S and 43 ± 11.5 minutes in Group L, both with significant differences between groups (P < 0.05).Conclusions In this study, we observed that intravenous lipid emulsion (ILE) administration shortened the motor block duration in rats undergoing sciatic nerve block with a percutaneous approach. Additionally, reductions in sensory and deep sensory block durations were also detected following ILE administration. Although the obtained data suggest that ILE shortens the block duration in peripheral nerve blocks, more comprehensive randomized controlled trials are needed to guide clinical practice.