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Imagine attending a busy shift in a paediatric emergency department (ED). You have just read two recent and rigorous publications; one facilitated risk stratification for clinically important traumatic brain injury (ciTBI) following minor trauma, while the second does the same for lethal paediatric malignancies following CT. Your next patient presents with minor head trauma. Evidence now estimates their risks for both ciTBI and for iatrogenic malignancies at equilibrium; 1:5000. What would you do? What disparity between these odds should change your response, and what could?