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Paracetamol and pregnancy: the importance of confounding

archdischild · 2025-10-17 · canonical JSON source

10 visible annotations · policy: published · automated confidence ≥ 75.00%

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Archivist appreciates that this paper may not be recent, but it may be useful for current discussions with families. It is an important question … Does paracetamol use during pregnancy increase children’s risk of neurodevelopmental disorders such as autism? Ahlqvist VH, et al (JAMA 2024;331(14):1205–1214. doi:10.1001/jama.2024.3172) have examined the associations of paracetamol use during pregnancy with children’s risk of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD) and intellectual disability. It is a Swedish, nationwide population cohort study of 2 480 797 children born from 1995 to 2019, with follow-up through 31 December 2021. The most important feature of the study design was that they used sibling control analysis. Some previous studies that had not used sibling controls have shown a marginally increased association with ASD and ADHD.