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This study aimed to explore whether baseline values and 12-month change in the 6-Minute Walk Distance (6MWD) and the physical scale of the Minnesota Living with Heart Failure Questionnaire (MLHFQ) were associated with long-term mortality in patients with heart failure (HF).Methods A total of 333 patients with HF, enrolled in the HF-Wii trial ( NCT01785121) in Sweden, were included. Data on long-term mortality were gathered 3 years after study completion of the last patient included. Study participants were stratified into three groups based on baseline results of the 6MWD: group 1: ≤383 m, group 2: 384–450 m and group 3: ≥451 m. Similarly, tertiles were formed according to baseline MLHFQ physical domain scores: group 1: 0–5 points, group 2: 6–12 points and group 3: 13–40 points.Results During a median (25th–75th percentiles) follow-up of 1900 (1566, 2271) days, 48 patients died (14.4%). Patients in group 1 of 6MWD displayed a more severe clinical status in comparison to patients in groups 2 and 3. Kaplan-Meier survival analysis showed a statistically significant between-group difference in survival, observed per tertile groups of the baseline 6MWD. However, no significant difference in survival was found in relation to changes in 6MWD over time. Likewise, there were not statistically significant between-group differences in survival per tertile groups of the baseline score on the physical domain of MLHFQ nor with respect to change over time of the same score.Conclusions Baseline 6MWD demonstrated significant prognostic value for long-term mortality in patients with HF whereas the physical score of MLHFQ, as well as their 12-month changes did not reach statistical significance.Trial registration number NCT01785121.