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Background Patients with advanced or metastatic squamous cell non-small cell lung cancer (NSCLC) have several combined chemotherapy plus immunotherapy (IO) options for first-line treatment that have shown significant improvements in survival versus chemotherapy alone. The optimal selection and use of these agents, however, depends on several clinical factors, including performance status, biomarkers such as PD-L1 expression, and toxicity profiles. Real-world factors such as patient preferences and treatment burden may also impact selection.We aimed to determine if digital, short-form, case-based medical education could improve oncologists’ knowledge and competence related to individualizing first-line chemo-IO treatment for patients with advanced or metastatic squamous NSCLC without molecular alterations.Methods US-based academic and community medical oncologists participated in a digital, 15-minute, case-based accredited medical education activity, ‘Squaring Off With Squamous NSCLC: The Latest Evidence and Guidance on Chemoimmunotherapy Options,’ consisting of video and slides. The activity launched on June 27, 2024. Pre- and post-activity assessments were used to collect information regarding learners’ baseline scores as well as the impact of the education on knowledge and competence. Assessments were analyzed in aggregate and at the individual level.Results As of May 29, 2025, 2,102 clinicians had participated in the education. Data collection is going. An overall increase in knowledge and competence of 31% was observed as the result of the education. Specifically, participants improved their ability to distinguish among chemo-IO combinations by 55% and individualize treatment by 37%. Baseline knowledge was lowest regarding the efficacy and safety of these combinations. 81% of participants expressed their intention to make changes to their practice based on the activity. Participants reported seeing an average of 10 to 13 patients per week with NSCLC, suggesting the education has the potential to impact 19,575 patient interactions.Conclusions Digital, short-form, case-based CME improved knowledge and competence related to individualizing first-line chemo-IO treatment of patients with advanced or metastatic squamous NSCLC without molecular alterations.