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Please confirm that an ethics committee approval has been applied for or granted: Yes: I’m uploading the Ethics Committee Approval as a PDF file with this abstract submissionBackground and Aims Thoracic surgery, vital for treating a range of pulmonary and mediastinal conditions, is often accompanied by intense postoperative pain, presenting a significant challenge in patient care. One promising approach that has garnered attention for addressing post-thoracotomy pain is the erector spinae plane block (ESPB). The site of action is ventral and dorsal rami of thoracic spinal nerves extending from T3 to T10. Leveraging the anatomical accessibility and nerve-blocking properties of the erector spinae muscle group, ESB holds promise as an adjunct to traditional analgesic modalitiesMethods A total of 76 patients were included in the study. All captured data was recorded manually and then presented in the form of frequencies (percentages) in tabulated form in Microsoft Word Office 365. All calculations were done manually.Results A total of 76 erector spinae plane block related catheters were inserted in thoracic surgery patients. Tuohy’s needle was used for ESPB. Mean needle depth was 5 cm and mean catheter depth was 11 cm. Different concentrations of local anesthetics were used (0.1%, 0.2% and 0.25%) at different infusion rates (10 ml/hour up to 20 ml/hour). No complication was encountered during our study period.Conclusions Erector Spinae Plane Block provides the best pain relief with minimum complication risks and maximum postoperative benefits, including its use in patients with coagulopathy and systemic infections. So, ESPB catheter-based analgesia with continuous infusion (0.15 or 0.2% bupivacaine at 15–20 ml/hour) should be the preferred mode of postoperative analgesia after thoracic surgery and the catheter can be kept for a maximum of 6 days. Hence, a collaborative approach is required between the thoracic surgeon and the anesthetist.