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Recent advances in cancer neuroscience are reshaping our understanding of neuroimmune interactions in malignancy. The autonomic nervous system is increasingly recognised as a distributed network of anatomically and functionally specialised neuronal circuits that engage in reciprocal communication with stromal, immune and parenchymal cells across peripheral organs, including the liver. This conceptual shift has been especially influential in cancer biology, where neural inputs are increasingly recognised as active contributors to the acquisition of malignant traits.1