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The PhD project centred around the ‘Power Training in Older People with Multiple Sclerosis’ (PoTOMS) trial ( figure 1). The primary aim of the PoTOMS trial was to compare the effect of a 24-week progressive power training programme (PPT) on whole-brain atrophy rate in older people with multiple sclerosis (MS). The secondary aim was to investigate the effects of PPT on brain microstructures and macrostructures, walking capacity, and neuromuscular function (i.e., interaction between the nervous system and skeletal muscles).