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Background Turner Syndrome (TS) patients have an increased risk of aortic enlargement and subsequently, dissection. We aim to summarise data on aortic growth in Leeds Teaching Hospital Trust (LTHT) TS patients to evaluate whether it supports this literature, and whether risk factors (hypertension and congenital heart disease (CHD)), length of follow-up, and mode of imaging influence results.Methods Retrospective analysis of electronic records of LTHT TS patients 2009-2025. Data collected includes demographic data, aortic measurements (sinus of Valsalva (SoV) and ascending aorta (Asc Ao)) from two separate scans, and outcome data.Results 172 patients. Median age 34 years (IQR 28-46). Median BMI 27.2. Mortality 5.81%, median age at death 64 years. Four patients had aortic dissections (3 emergency repair, 1 death). 13 patients had elective aortic surgery (73.3% Bentall, 26.7% valve sparing). 72 excluded due to insufficient data or aortic surgery altering results. Of the 100 patients, 52 underwent two MRIs, 33 one MRI and one echocardiogram, and 15 two echocardiograms. Follow up intervals <5 years (n=12), 5-10 years (n=52), >10 years (n=45). 25 patients had hypertension and 32 had CDH. Mean difference in Asc Ao 0.34mm/year (SD 0.80), and SoV 0.38mm/year (SD 0.72). Data was analysed using unpaired T-test and ANOVA. Those with CHD (SoV P=0.04, Asc Ao P=0.021) and longer duration of follow up (Asc Ao P=0.01) had higher rates of aortic growth. The results for hypertension were conflicting (SoV P=0.41, Asc Ao 0.04). Patients with 2 scans of the same imaging modality were more likely to document aortic growth (SoV P=0.02, Asc Ao P=0.02).Conclusion Higher aortic growth rates occur over time and in those with CHD, but results were conflicting for hypertension. There were potential inaccuracies comparing imaging from different modalities. Future Longitudinal studies into this would be appropriate.Abstract 509 Figure 1