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Objectives This study aimed to evaluate the prevalence of musculoskeletal disorders (MSDs) among Tunisian radiologists, identify occupational risk factors associated with these disorders in this professional group, and assess their functional impact.Methods A cross-sectional survey was conducted using a questionnaire via Google Forms. It included four sections: sociodemographic and professional data; the Nordic Musculoskeletal Questionnaire (NMQ); the Roland-Morris Disability Questionnaire; and items related to predictive factors.Results A total of 73 radiologists participated in the study. They were predominantly aged between 36 and 55 years (70.8%), with 56.9% were women. The mean work seniority was 13,23 years. Most reported working 6 to 7 hours per day (77.8%) and using multiple imaging modalities: ultrasound (100%), computed tomography (100%), conventional radiology (90.3%), MRI (86.1%), and interventional radiology (54.2%). The majority (80.6%) reported working primarily in a seated position while 19.4% alternated between sitting and standing throughout their workday. Over the past 12 months, the most frequently reported sites of MSDs were the right shoulder (83.3%), neck (63.9%), and lower back (61.1%). Recent pain (past 7 days) was commonly reported in the lower back (52.8%) and upper back (27.8%). Functional limitations due to pain were reported in the lower back (13.9%) and right wrist/hand (47.2%). Regardind the Roland-Morris Disability Questionnaire; main impacts were fatigue (50.7%) and anxiety (49.3%). To relieve pain, most participants reported changing posture frequently (82.6%) and taking breaks (71%). A majority expressed interest in training and awareness programs (93%), ergonomic workstation assessments (83.1%), and preventive exercises (63.4%).Conclusion MSDs are prevalent among Tunisian radiologists and significantly affect their physical and psychological well-being. There is a critical need for targeted ergonomic interventions, structured training programs, and workplace adjustments to prevent and manage MSDs in this population.