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Bronchiectasis is a chronic lung condition in which the presence of certain comorbidities is associated with poor patient outcomes. The presence of multimorbidity, 2 or more chronic conditions, in the general population also has an established association with poorer health outcomes. This study aimed to establish the prevalence of comorbidities and multimorbidity in the BronchUK registry and determine the associations between multimorbidity in bronchiectasis and health related quality of life (HRQoL), exacerbation severity/frequency and mortality.Methods 3 comorbidity counts (CC) were derived, representing a basic, intermediate and extended selection of the comorbidities in the BronchUK Registry. The association between multimorbidity as per these CCs and HRQoL (measured by the total St George’s Respiratory Questionnaire (SGRQ) score) at baseline was investigated using linear regression analysis. The association of multimorbidity with more severe (measured by hospitalisation)/frequent (measured by an incidence of 3 or more annually) exacerbations and mortality over 5 years were investigated using logistic regression analysis. This approach was also to investigate the association between comorbidities and mortality.Results Multimorbidity was a common finding in 1548 patients analysed, present in 54.1% to 96.2% of patients in the basic and extended CCs respectively. Having 2 comorbidities was associated with a clinically significant increase in SGRQ score and a poorer HRQoL (minimum score increase: 4.68-points (95% CI: 2.88–6.48). An increased odds of more frequent or severe exacerbations, OR=2.02 (95% CI: 1.05–3.87), was associated with having 5 comorbidities and an increased odds of mortality, OR=3.04 (95% CI: 1.42–6.49), As expected Pseudomonas, prior hospitalisations were linked with death. Individual comorbidities linked with death on univariate analysis included CCF, Chronic Renal Failure, AF, CTD, Osteoporosis, COPD, Tuberculosis, Depression, Diabetes and GORD.Conclusions We found that multimorbidity is common in bronchiectasis and is significantly associated with a poorer HRQoL, more frequent/severe exacerbations and mortality. In line with other work, several individual comorbidities showed a stronger association to mortality than others. It is therefore important to consider multimorbidity, as measured by CCs, when considering the management of bronchiectasis patients.