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A single gut wall perforation in a baby is known as spontaneous intestinal perforation, and it usually happens at the terminal ileum. It is a potentially fatal illness that affects newborns who have very low birth weight and extremely low birth weight (less than 1000 g). Low birth weight and prematurity are important risk factors. This is a case study of a preterm neonatal male having neonatal respiratory distress syndrome along with respiratory distress syndrome who was born with a weight of 1.08 kg via lower-segment caesarean section. As the infant was suffering from respiratory distress syndrome, he received a physiotherapy call to manage the symptoms. The thoracic squeeze technique and Yakson technique proved very helpful for the child to recover from the condition. The whole treatment procedure was performed with proper assessment by using the Silverman–Anderson respiratory distress score scale; face, legs, activity, cry and consolability scale; and Ballard score.