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“Can our medical student tell us which organ systems need to be monitored now that we’ve started this patient on amiodarone?” It’s a familiar scenario: the team pauses, their eyes land on you, and the attending physician has asked you a question on ward rounds that you just can’t answer. You tell yourself that you should know it. Maybe you make a few guesses, remark that you remember seeing it at some point, or stammer anything to stop from sounding clueless. It feels like an intellectual, or even a moral, failing. But being uncertain can actually be our most powerful ally in medicine, and some insights from philosophy can tell us why.