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We read with great interest the recent publication by D’Souza et al,1 titled “Implantable peripheral nerve stimulation for chronic pain: a systematic review and meta-analysis of analgesic outcomes up to 24 months.” They concluded that their results demonstrated clinically meaningful reductions in pain intensity and provided evidence to inform clinical decision-making and payor policy. This communication aims to highlight several methodological shortcomings that we believe warrant a reconsideration of these conclusions.