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Please confirm that an ethics committee approval has been applied for or granted: Yes: I’m uploading the Ethics Committee Approval as a PDF file with this abstract submission Application for ESRA Abstract Prizes: I apply as an Anesthesiologist (Aged 35 years old or less)Background and Aims Effective postoperative pain management is vital for recovery, especially after major abdominal surgeries like open nephrectomy. The quadratus lumborum block (QL) is a promising regional anaesthesia technique that targets somatic and visceral pain pathways.Methods We report a 62-year-old Filipino, female, who underwent open nephrectomy, left, under general anaesthesia. Following induction and endotracheal intubation, an ultrasound guided QL block was performed with 20 mL of 0.3% ropivacaine while the patient was on right decubitus position. During intraop, no additional opioids were required to maintain surgical anaesthesia. The procedure was uneventful with no complications. Postoperatively, at 0, 1, 2, 3 and 6 hour, the patient reported a numeric pain score of 0 and demonstrated excellent recovery, including the ability to sit and ambulate comfortably on the same day. No additional opioids was necessary during the 24 h postoperative period. The patient resumed activities early and was discharged on postoperative day 5 with completed antibiotics and without complications.Results This case highlights the efficacy of the QL block in managing postoperative pain for open nephrectomy. The use of 0.3% ropivacaine ensured adequate pain relief and facilitated early mobilization, while avoiding common opioid-related side effects such as nausea and vomiting , pruritus, sedation, ileus and among others.Conclusions The QL block is a safe and effective option for postoperative pain control in open nephrectomy, promoting enhanced recovery. Further research may support its broader application in other abdominal surgeries.