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Objectives To synthesise implementation research and evaluation findings from the Baby Ubuntu programme—an early intervention designed to support young children with developmental disabilities and their families in low- and middle-income countries.Methods Using the RE-AIM framework, we analysed data from eight studies conducted between 2013 and 2026 in Uganda and Rwanda. Studies included qualitative research, mixed-methods evaluations, a feasibility trial, and economic analyses. The programme, co-designed with expert caregivers, consists of 11 co-designed modules facilitated by expert parents promoting inclusion, development, and caregiver empowerment.Results The programme demonstrated strong demand and feasibility in rural and urban settings, with >80% attendance despite stigma and financial barriers. Evaluations showed 20–25% improvements in family quality of life and increased caregiver confidence, hope, and child developmental progress. Healthcare provider training significantly improved knowledge and referral practices. Implementation was cost-feasible (~$161 per participant), and all 26 eligible health centres in the ongoing Rwanda trial adopted the intervention. Key enablers included community sensitisation, transport facilitation, and co-facilitation by caregivers. Barriers included geographic access, caregiver isolation, and workforce constraints. Knowledge gaps remain on scaling within government systems and sustaining long-term impact.Conclusions Baby Ubuntu offers a replicable and sustainable early intervention model supporting children with neurodevelopmental disabilities and their families. Findings inform integration strategies into health systems and ongoing evaluation in Rwanda.