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Histiocytic sarcoma (HS) of the small intestine is exceedingly rare. We report a woman in her early 50s who presented with acute abdominal pain and was found to have two synchronous jejunal intussusceptions caused by multifocal HS. Emergency laparoscopy converted to open resection revealed multiple jejunal tumours; pathology confirmed HS with mesenteric nodal metastasis. Although 13 tumours were identified, only two lesions served as lead points for intussusception. All tumorous lesions were resected. The patient was recommended adjuvant therapy but declined and died 12 months later. This case underscores the need to consider rare neoplasms in adult intussusception, perform thorough intraoperative exploration and obtain extensive histopathology and immunohistochemistry for diagnosis.