Document resource
Introduction The iNtercept device (iVascular) with the self-expanding basket fixed to a pusher wire is a last-generation stent-retriever (SR) designed for mechanical thrombectomy (MT)Aim of Study We assessed the noninferiority of iNtercept versus contemporary SRs (CSRs)Method We analyzed data from the ROSSETTI multicenter, prospective registry of patients with anterior circulation large vessel occlusion (LVO) to compare clinical and radiological data of patients treated with iNtercept or CSRs as a first-line strategy, with or without balloon-guide catheter (BGC). Procedural, clinical (modified Rankin Scale at 90 days), and safety (symptomatic intracranial hemorrhage, mortality at 90 days) outcomes were compared after propensity score matching. Noninferiority of iNtercept was established if the prespecified lower bound of the 95% confidence interval was over −10%.Results 164 and 128 patients treated first-line by iNtercept were matched to 656 and 729 patients treated first-line by CSR+BGC and CSR without BGC, respectively. After matching, successful reperfusion after first-line strategy was achieved in 53.7% and 54.8% in the iNtercept and CSR+BGC groups, respectively (absolute difference, -0.1%), and 53.8% and 53.9% in the iNtercept and CSR without BGC, respectively (2.6%). Final reperfusion rates and favorable 90-day outcomes were similar. iNtercept had fewer sICH, procedural complications, and emboli in a new territory than CSR+BGC, and fewer procedural complications compared to CSR without BGCConclusion This study demonstrated the noninferiority of iNtercept compared with CSR for successful reperfusion. However, iNtercept had better safety profile and similar favorable outcomes at 90 daysConflict of Interest No