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Home mechanical ventilation (HMV) is a life-saving treatment for patients with chronic respiratory failure due to different underlying diseases.1–4 Striving for value-based care, that is, high-quality care with optimal use of resources, telemedicine for ventilator-dependent patients holds promise.5 Telemedicine might improve efficiency and quality of HMV care, empower patients and informal caregivers,6–8 enable care at home and broaden access to care, particularly in resource-constrained settings. Telemedicine ideally offers the potential to reduce inpatient care needs,9–11 lower healthcare costs10 11 and foster a more patient-centred approach. Yet, as its adoption increases, important questions arise regarding its actual effectiveness, feasibility and generalisability in chronic respiratory care.