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Background and Aims Intravenous dexamethasone and dexmedetomidine are two adjuncts to local anaesthetics used independently to prolong analgesia after peripheral nerve block. This randomised, controlled, triple-blinded trial tested the hypothesis that the intravenous combination of dexamethasone and dexmedetomidine would provide superior analgesia than intravenous dexamethasone alone in patients undergoing upper limb surgery with a supraclavicular brachial plexus block.Methods A hundred patients were randomised to receive intravenously either dexamethasone 0.15 mg.kg-1 (Dexa group) or a combination of dexamethasone 0.15 mg.kg-1 and dexmedetomidine 1µg.kg-1 (Dexa-Dexme group). The primary outcome was the duration of analgesia measured from the time of block procedure to first oral opioid intake. Secondary outcomes included duration of sensory and motor blocks, pains scores at rest and on movement, cumulative oral morphine consumption at 48 h and incidence of hypotension episodes and bradycardia.Results The mean (standard deviation) duration of analgesia was 690 min (544 min) in the Dexa group and 621 min (334 min) in the Dexa-Dexme group (p=0.47). Similarly, there were no significant differences in all the secondary outcomes.Conclusions In conclusion, the intravenous combination of dexamethasone and dexmedetomidine does not provide superior analgesia than intravenous dexamethasone after a supraclavicular brachial plexus block.Abstract OP04 Figure 1This Kaplan-Meier curve describes the effect of intravenous dexamethasone and the combination of intravenous dexamethasone and dexmedetomidine on duration of analgesiaAbstract OP04 Figure 2Rest and dynamic pain scores during the course of the study. Means with 95% confidence interval are represented