Six at Sixty. ‘No gain, no pain’: medical genetics taking Nav1.7 from target to pharmacy

Pain perception is a vital protective mechanism.1 However, chronic pain, maladaptive and persistent, constitutes a major disease burden.2 Reliance on opioid analgesics is fraught with risks of tolerance, dependence, addiction and fatal respiratory depression, underscoring the urgent need for non-opioid alternatives.3–5