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Objectives To ascertain the effectiveness of supported online fatigue management programmes (FMPs) in patients living with Systemic Lupus Erythematosus (SLE) in the United Kingdom.Methods Here we present preliminary data from the FLIP Study, comparing standard care (fatigue management) to a 4-week, and a 7-week online FMP. Patient-reported outcome measures (PROMs) were collected at baseline, immediately post-intervention, and at 6-months post-intervention. PROMs included the Modified Fatigue Impact Score (MFIS); the Patient Health Questionnaire (PHQ4); the Pittsburgh Sleep Quality Inventory (PSQI), the Quick Systemic Lupus Activity Questionnaire (QSLAQ), and the Self-Efficacy for Managing Chronic Disease 6-Item Scale (SEMCD-6).Results There were no significant differences between arms at the point of randomisation in any of the PROMs (MFIS, p = 0.984; PHQ4, p = 0.207; PSQI, p = 0.673; QSLAQ, p = 0.745; SEMCD-6, p = 0.341). Using paired t-tests, participants of the 4-week FMP (n = 18) demonstrated significant improvements in all PROMs between baseline and 6-months post-intervention (MFIS, p = 0.003; PHQ4, p = 0.038; PSQI, p = 0.024; QSLAQ, p = 0.003; SEMCD-6, p = 0.03). Participants of the 7-week FMP (n = 13) demonstrated significant improvements between baseline and 6-months in the MFIS (p = 0.009) and PHQ4 (p = 0.011) but failed to reach significance in the other measures (PSQI, p = 0.148; QSLAQ, p = 0.09; SEMCD-6, p = 0.37). The standard care arm (n = 27) showed no significant improvement in any of the measures at 6-months (MFIS, p = 0.259; PHQ4, p = 0.848; PSQI, p = 0.770; QSLAQ, p = 0.593; SEMCD-6, p = 0.546). Figure 1 shows MFIS scores at baseline, post-intervention and 6-months post-intervention in the three arms.Abstract S16:02 Figure 1MFIS scores in the standard care, 4-week FMP, and 7-week FMP arms at baseline, immediately post-intervention, and at 6-months post-intervention. Lower scores indicate improvementConclusions Supported live-online FMPs significantly improve fatigue, mood, sleep quality, self-efficacy, and perceived disease activity in people living with SLE. The 4-week programme demonstrated consistent and sustained benefits across all patient-reported outcomes, while the 7-week programme only showed significant improvements in fatigue and mood, though respondent numbers were low. These findings suggest that structured, time-limited, online interventions can provide an effective and accessible approach to managing fatigue in SLE, offering a valuable addition to routine care.