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Data gathered from the COVID-19 Clinical Neuroscience Study has demonstrated that COVID-19 infection is associated with post-acute objectively measurable cognitive deficits. This is significant not only for COVID-19 but for other post-infectious cognitive syndromes. This cohort and others have indicated that age, covid severity and education status are important baseline predictors of greater cognitive deficits post COVID-19 illnessExtant literature has shown that anticholinergic burden, frailty and multimorbidity are associated with cognitive decline. We therefore hypothesised that clinical frailty score, multimorbidity and anticholinergic drug burden are also associated with poorer cognitive outcomes in this same group of COVID-19 patients, and could be used to refine a predictive model of post-infection associated cognitive impairment.Multivariate analysis using Kruksal-Wallis testing amongst a cohort of 310 patients with COVID-19 has not shown these parameters to correlate with worse cognitive scores. Limitations to this analysis include cognitive data being collected at a singular time point post-acute infection.Identification of risk factors for those patients at greatest risk of cognitive impairment following acute systemic infection such as COVID-19 has implications for other post-infectious cognitive syndromes and for future pandemics. Further longitudinal cognitive assessment will prove valuable in demonstrating potential associations with such variables.rachaelmatthews1990@gmail.com