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Objective Identify predictors for mortality and clinical short-term outcomes in patients with left-sided infective endocarditis (IE).Methods This study was a retrospective cohort investigating 376 patients who experienced left-sided IE between 1 January 2013 and 31 December 2022, at the National Cardiovascular Center Harapan Kita Hospital. Bivariate and multivariate statistical analyses were conducted to identify predictors of short-term clinical outcomes.Results The study comprised 376 patients with left-sided IE who received standardised antibiotic therapy, with 56.6% of them undergoing surgical intervention. The observed short-term mortality rate was 18.6%. Furthermore, the morbidity profile during the treatment phase revealed the following incidences: sepsis in 27.1% of cases, intensive care unit stay exceeding 10 days in 18.6% of cases, mechanical ventilation for more than 7 days in 11.4% of cases, stroke in 28.5% of cases and acute renal failure in 57.7% of cases.Conclusion Predictors of short-term mortality outcomes in patients with left-sided IE included New York Heart Association functional class III–IV, aortic valve vegetation involvement, vegetation size ≥10 mm, incomplete antibiotic administration, sepsis and the requirement for renal replacement therapy.