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Background In the UK, some policies targeting foods high in fat, sugar, or salt (HFSS) (limiting HFSS placement, advertising, and promotions) have been introduced to address obesity and diet-related diseases. However, evidence on the impacts of other policy options remains limited. We estimated the health and economic impacts of taxation and nutrient warning labelling on HFSS products in England.Methods We used the IMPACT NCD, a validated open-cohort microsimulation model, to estimate the impacts of i) 8% taxation, ii) nutrient warning labelling, and iii) both combined on HFSS products in adults (30-99 years) in England over 15 years (2026-2040). A synthetic population was created using nationally representative surveys and routine administrative data. We estimated the policy impacts primarily based on assumed consumer-driven changes in energy and salt intake. Potential industry reformulation was modelled in sensitivity analyses.Results Implementing an 8% tax on HFSS products would reduce obesity prevalence by 2.19 percentage points [95% uncertainty intervals(UI): (1.69-2.73)], prevent 83,000 [95%UI: (55,000-130,000)] cardiovascular diseases (CVDs), and save £53 billion [95%UI: (41-67)] from a societal (health, social care, informal care, productivity) perspective over 15 years. Nutrient warning labelling would reduce obesity prevalence by 0.48 percentage points [95%UI: (0.20-0.85)], prevent 24,000 [95%UI: (10,000-41,000)] CVDs, and save £14 billion [95%UI: (6.2-24)]. The implementation of both policies together would yield greater benefits with a 2.66 percentage-point [95%UI: (2.09-3.28)] reduction in obesity prevalence, 110,000 [95%UI: (68,000-150,000)] CVDs prevented, and £66 billion [95%UI: (52-82)] saved. All the policy scenarios were estimated to be cost-effective and have greater impacts on deprived groups. Sensitivity analyses, which assumed industry reformulation would reduce coverage of liable HFSS products subject to either taxation or nutrient warning labelling, yielded similar impact estimates.Conclusion Implementing both taxation and nutrient warning labelling as additional measures to reduce HFSS consumption could be an effective policy to tackle obesity and diet-related diseases in the UK.