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Home Parenteral Nutrition (HPN) provides life-sustaining nutritional support for children with intestinal failure 1; this requires a Central Venous Catheters (CVC).2 CVCs are prone to complications necessitating replacement such as Central Line-Associated Bloodstream Infection (CLABSI) and mechanical issues: these include line fractures, displacement, thrombotic events and blockages.3 This study reviews CVC lifespan and complications amongst HPN patients.We report a retrospective review of electronic records of all HPN patients managed from September 2021-September 2025. Data was collected on demographics, indication, lifespan, complications, repairs and replacements.26 patients were reviewed with a mean age of 8.7 years. A total of 78 CVCs were inserted. A total number 35,222 catheter days were studied. The median lifespan was 330 days (IQR 21-630). The complication rate was 1.68 events/1000 CDs.52 of 78 CVCs were replacements. 14 of the 52 CVC replacements followed failed line repairs; half of the total repairs were unsuccessful. CIPO patient cohort contributes to a higher proportion of line replacements.67% of complications were due to mechanical issues such as line fracture (34%) and line blockage (33%). There were 6 incidents of line cuff displacement outside the skin. There were no reported thrombotic events. Of the CLABSI events, 11 CVCs were salvaged. One CIPO patient accounted for 10 replacements.The median CVC lifespan in this cohort compares with literature, where survival ranges between 200–400 days.1 4 Complication rates are equally comparable.1 3 5 The rate of successful line repairs does not compare favourably to literature2; assessment of repair techniques is desirable.The incidence of mechanical complications is lower than reported in literature (3.37 events/1000 CDs).3 Whilst our numbers of line fracture and occlusion correlate with published studies, our numbers demonstrate higher incidences of cuff displacement.3 5 This is an area that prompts further investigation into the existing processes/surgical techniques.The cohort’s total CLABSI rate replicates results from published studies (0.57-2.1 events/1000 CDs).1 3 5 The significantly higher rate of CLABSIs in CIPO patients implies additional vascular protection work should be implemented with this cohort. CVC lifespan secondary to complications remains a significant challenge in HPN care. Our centre experience suggests that review of the approaches toward surgical repair and surgical techniques are required to reduce complication rates. The CIPO cohort has a notably increased CLABSI rate, which needs addressing. This review offers valuable insights into planning quality improvement initiatives for optimising CVC management for paediatric intestinal failure patients.References Gandullia P, Lugani F, Costabello L. Long-term home parenteral nutrition in children with chronic intestinal failure: a 15-year experience at a single Italian centre. Dig Liver Dis. 2011 Jan;43(1):28–33.Zaidi Z, Littlechild H, Hill S. Causes and outcome of central venous catheter repair in children with intestinal failure on home parenteral nutrition. J Pediatr Gastroenterol Nutr. 2023 Dec 1;77(6):796–800.Hartman C, Shamir R, Simchowitz V. ESPGHAN/ESPEN/ESPR/CSPEN working group on paediatric parenteral nutrition. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: complications. Clin Nutr. 2018 Dec;37(6 Pt B):2418–2429.Hojsak I, Strizic H, Misak Z. Central venous catheter related sepsis in children on parenteral nutrition: a 21 year single centre experience. Clin Nutr. 2012 Oct;31(5):672–675.Unal KN, Park T, Lopez LG. Investigation of urgent reasons for central venous catheter replacements and outcomes in paediatric home parenteral nutrition patients. Frontline Gastroenterol. 2025;16:34.Abstract OC56 Table 1CVC complication/repair dataIndicationNumberCLABSINumber%Episodes/1000 CDs*Mechanical IssueNumber%Episodes/1000 CDsRepairNumberEpisodes/1000 CDsReplacementNumberEpisodes/1000 CDsLifespan monthsRangeSurgical Short Gut143(10.1%)0.1425(89.9%)1.2100.48170.8228.70.1-107Motility43(27.3%)0.518(72.7%)1.3430.5171.2819.57-58Enteropathy33(42.9%)0.674(57.1%)0.8910.2251.1211.63-32CIPO516(55.2%)2.213(44.8%)1.7450.67233.097.60.5-60Total2625(33%)0.6450(67%)1.3290.75521.3416.90.1-107*CDs: Catheter Days