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Background and Aims Gluteal tendinopathy is a common condition causing lateral hip pain. It is also a common comorbid cause of chronic pain. Hydro dissection, a minimally invasive technique involving injection of fluid to separate fascial layers and release entrapped nerves and tendons, has emerged as a potential treatment. Its use in Gluteal Tendinopathy has not been reported.Methods We present the case of a 67-year-old female with refractory left gluteal teninopathy confirmed on MRI imaging. Despite extensive conservative therapies, including medications and physical therapy, she continued to experience left lateral hip pain.The patient underwent ultrasound-guided gluteal tendon hydrodissection as a targeted approach to address perineural inflammation and nerve entrapment. Hydrodissection of the gluteus maximus and gluteal medius tendons was performed on the left side. A low concentration (5%) dextrose solution was used to free the tendons from surrounding scar tissue and muscle adhesions. The procedure was performed in a theatre setting.Results Following the hydro dissection procedure, the patient experienced improvement in lateral hip pain, with sustained improvement over two months, at follow-up. Functional outcomes, including range of motion and daily activities, improved substantially. No complications were reported.Conclusions This case supports the potential role of dextrose hydro dissection as a safe, minimally invasive treatment option for gluteal tendinopathy. Hydro dissection offers an alternative to more invasive interventions and warrants further investigation in the management of Gluteal tendinopathy.