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Introduction Systemic sclerosis is a disorder characterized by fibrosis of skin and visceral organs. The disease tends to be very severe in males with early organ involvement.Material and Methods To study clinical, immunological and treatment profile of male scleroderma patients from Northern India .31 male scleroderma patients who met the 2013 ACR EULAR classification criteria were included in the study. Their demographic, clinical, autoantibody profile and treatment protocol were recordedResults Median age of study population was 38(15) years with a mean duration of 60(108) months.19 patients (61%) had diffuse cutaneous (dcSSCc) and 10(32%) patients had limited cutaneous (lc SSc) and 2 (6%) patients had sine SSC. Vasculopathy is the predominant manifestation in 28(90%) of the patients. Other systems involved were musculoskeletal in 19(61%), pulmonary in 19(61%) and Gastrointestinal manifestations in 18(58%) patients. Three patients had scleroderma renal crisis. Three patients had overlap with other rheumatic diseases. 25 (80%) patients were ANA positive with Scl70 being the common autoantibody. Glucocorticoids were used in 14(52%) of patients. Cs DMARDS were used in 27(87.1%) of patients and more than 50% of patients required b DMARDS. One patient died in early phase of illness.Conclusions Early and severe organ involvement is seen in male systemic sclerosis and requires aggressive treatment to prevent progressionAbstract P.384 Table 1Demographics and clinical patterns