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Please confirm that an ethics committee approval has been applied for or granted: Yes: I’m uploading the Ethics Committee Approval as a PDF file with this abstract submission Application for ESRA Abstract Prizes: I apply as an Anesthesiologist (Aged 35 years old or less)Background and Aims Rebound pain is an increasingly recognized phenomenon following peripheral nerve blocks, marked by a sudden and intense return of pain as the block resolves. While extensively studied in elective orthopedic procedures, its relevance to patients with blast injuries remains unclear. Blast trauma presents a unique challenge due to the combination of high-energy soft tissue injury, nerve damage, and complex inflammatory responses. This review aims to evaluate whether rebound pain constitutes a true clinical issue in this population or is merely a theoretical construct extrapolated from other contexts.Methods A narrative review of existing literature was performed to explore the pathophysiological basis of rebound pain, its reported prevalence in trauma patients, and its possible impact in the setting of blast injuries. Data from military medicine, high-energy civilian trauma, and regional anesthesia research were examined.Results Although direct evidence in blast injury patients is lacking, several mechanisms—central sensitization, neuroinflammation, and abrupt reactivation of nociceptive pathways—may contribute to an exaggerated pain response following block resolution. Indirect reports from combat casualty care and trauma centers suggest that rebound pain may occur more frequently than documented, potentially leading to misinterpretation as inadequate anesthesia or undertreatment. This may result in excessive opioid use and delayed rehabilitation.Conclusions Rebound pain may represent a significant but under-recognized challenge in the management of blast trauma. Understanding its mechanisms and anticipating its occurrence are essential for effective analgesia. Implementation of multimodal pain strategies, proactive transition planning, and patient education may reduce its impact and improve outcomes. Further prospective studies are needed to confirm the incidence and clinical relevance of rebound pain in this unique and vulnerable patient group.