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Sexually transmitted infections (STIs) remain a major global public health concern, disproportionately affecting vulnerable populations such as migrants.1 2 Individuals arriving from sub-Saharan Africa often face a convergence of risk factors, including higher endemicity of infections in their countries of origin, limited access to healthcare and structural barriers after migration.3 4 In Spain, available data indicate higher prevalences of HIV, hepatitis B virus (HBV) and other STIs among migrants compared with the native population, yet prospective studies combining molecular and serological screening in asymptomatic individuals remain scarce.5 6