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The debate on prostate cancer screening is life, the universe, and everything boiled down to one question — and the answer isn’t 42. Whether or not men should be routinely screened for prostate cancer seems simple enough to answer, but only on the face of it. As two position statements from the UK’s National Screening Committee show — one on multicancer detection tests (doi:10.1136/bmj-2026-089868),1 the other on surrogate outcomes (doi:10.1136/bmj-2026-629407)2 — screening decisions are steeped in complexity.