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Background and Aims Sciatic nerve catheter is known to improve perioperative pain compared with single shot sciatic block. With healthcare cost increasing exponentially worldwide, we aim to analyze the cost effectiveness of sciatic nerve catheter compared with single shot sciatic nerve block for patients requiring repeated surgical interventions.Methods In this pilot study, we analyzed the anesthesia cost of two hypothetical patients in Ng Teng Fong General Hospital, who had sciatic nerve catheter inserted as the sole anesthesia for surgical procedure. These patients had surgical wounds only in the distribution of sciatic nerve and were expected to require repeated surgeries. The anesthesia cost was calculated based on local hospital cost framework.Results Patient 1 had sciatic nerve catheter inserted during first surgery and for pain management. Patient 1 subsequently had two more wound debridement which anesthesia was provided through top up of sciatic nerve catheter. The total anesthesia cost for three procedures performed under sciatic nerve catheter top up was USD442.96. If patient 1 had received three single shot sciatic nerve block, the total anesthesia cost would be USD599.99, which was 35.4% more expensive than using sciatic nerve catheter top up. Patient 2 had sciatic nerve catheter inserted during first surgery and had catheter top up for a subsequent procedure. His total anesthesia cost for the two procedures under sciatic nerve catheter top up was USD419.60. If Patient 2 had received two single shot sciatic nerve block for these two procedures, the total anesthesia cost would be USD399.99, which was 4.7% cheaper than performing anesthesia under sciatic nerve catheter top up.Conclusions Sciatic nerve catheter provide good cost-effectiveness for patients requiring more than one surgical procedure. Even if only one additional procedure was performed with catheter in-situ, the total anesthesia cost was only slightly more expensive than if two single shot sciatic nerve block was performed.