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Introduction Large (LBA) and Super Large Bore Aspiration (SLBA), have shown high rates of First-Pass Efficacy (FPE) during mechanical thrombectomy. The utilization novel atraumatic delivery catheters has provided adequate support to safely and efficiently reach the clot with large/super-large bore catheters, without need for crossing the occlusion.Aim of Study We performed a comparison of novel atraumatic delivery catheters actually on the market (SENDit; Tenzing7&8; Cheetah; Zipline; Innerglide; CarrierSM,MD&LG) or in advanced testing phase (FastPass) analyzing the different features, especially in combination with the paring aspiration catheters on the market (RED72; FreeClimb70&88/HiPoint88; Hippo072; Millipede088; Cereglide71&92; Ballast088) or in advanced testing phase (Broadway84).Method These platforms entail the utilization of a triaxial assembly: guide/long sheath catheter with/without balloon, 0.070’/72’ or 0.084’/92’ reperfusion catheter and insert catheter that completely consumes the inner diameter of the large-bore or super large-bore aspiration catheters.Results These novel atraumatic delivery catheters have proven superior capability in navigating the matching reperfusion catheters to the proximal aspect of the occlusion. The virtually atraumatic self-centering soft tapered tip is capable to cruise the tortuous cervical-cranial vasculature. The extremely large shaft almost zeroes the step-off with the aspiration catheters and reduces the risk to get stuck at vascular ledges/bifurcations, making unnecessary to cross the embolus, significantly reducing the risk of downstream clot embolization.Conclusion Building scientific evidences has demonstrated the elevated safety and efficacy of this new generation of stroke-dedicated platforms combining large-bore/super large-bore aspiration catheters to novel atraumatic and self-centering delivery catheters.Conflict of Interest No