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This thesis investigated the reliability, measurement, determinants, acute changes, and chronic adaptability of running economy (RE) during prolonged running and compared temporal changes (ie, durability 1) between physiological determinants of endurance performance in well-trained male runners. It was hypothesised that RE durability would vary between athletes according to performance level and running training characteristics, that strength training would enhance RE and fatigued performance and that durability would differ between physiological determinants.