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Background and Aims Complex Regional Pain Syndrome (CRPS) is a challenging chronic pain condition with multifactorial causes, often arising after surgical trauma. Hyperbaric oxygen therapy (HBOT) has emerged as an adjunctive treatment designed to promote tissue oxygenation and reduce inflammation. This case report explores the use of HBOT in a patient with CRPS resistant to conventional therapy.Methods We report a case of a 44-year-old woman who developed CRPS within one year following surgery for the excision of Morton’s neuroma, which was complicated by sesamoid necrosis. Despite treatment with corticosteroids, vitamin C, and acetylcysteine, her symptoms persisted. She subsequently underwent 80 HBOT sessions.Results The patient experienced transient improvement in pain intensity and functional capacity during the treatment period. HBOT is believed to exert its effects by increasing oxygen delivery to ischemic tissues, modulating inflammatory responses, and facilitating cellular repair. In this patient, the temporary relief observed suggests that while HBOT can yield short-term benefits, its effects may not be sustained once sessions are discontinued. This outcome signals the need for further investigation into optimal session protocols and potential combination therapies to achieve lasting symptom control in CRPS.Conclusions This case highlights that HBOT may offer a viable option for transient symptom relief in CRPS unresponsive to standard treatments. However, its long-term efficacy remains inconclusive. Further controlled studies are essential to establish the role of HBOT within a comprehensive, multimodal treatment strategy for patients with CRPS.