Letter to the editor: caution in translational leap – are the data sufficient to generalize low-dose PDT to chest malignancies?

We read with interest the study by Chriqui et al, which explores the immune-modulatory role of low-dose photodynamic therapy (L-PDT) in promoting vascular E-selectin expression and CD8+ T-cell infiltration in thoracic malignancies.1 Their mechanistic work in murine models is elegant and their observations in pleural mesothelioma (PM) samples provocative. However, we are concerned that the translational conclusions, particularly with respect to non-small cell lung cancer (NSCLC), extend well beyond the evidence base presented.