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Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory connective tissue disease that can affect multiple organs, with ocular involvement occurring in approximately one-third of patients. Ocular findings may include keratoconjunctivitis sicca, episcleritis, scleritis, optic neuropathy, retinal vasculitis, and uveitis. Although uveitis is an uncommon manifestation of SLE, its prevalence among patients with uveitis has been reported to range between 0.1% and 4.8%. The aim of this study was to evaluate the clinical and laboratory features of uveitis in patients with SLE.Methods A total of 277 patients diagnosed with SLE according to the 2019 ACR/EULAR classification criteria and followed in our clinic during the past seven years were retrospectively evaluated. Demographic, clinical, and laboratory data were obtained from medical records. Disease indices (anti-dsDNA, anti-Sm/RNP, antinuclear antibody, anti-Sm, complement levels), additional organ involvement, and treatments were recorded. Statistical analyses were performed using SPSS version 25 (IBM Corp., Armonk, NY). Variables were expressed as mean, median, frequency, and percentage.Results Among 277 SLE patients, 7 (2.5%) were found to have uveitis. Of these, 5 patients (71.4%) were female and 2 (28.6%) were male, with a mean age of 52.3 years. Two patients had anterior uveitis, two had posterior uveitis, and three had panuveitis. Unilateral ocular involvement was observed in five patients (three left, two right), while two patients had bilateral involvement. The most frequent ANA pattern was granular (n=4), followed by speckled (n=1) and nuclear (n=1). Anti-dsDNA positivity was observed in one patient, anti-Sm in one, and anti-Sm/RNP in four patients. The mean erythrocyte sedimentation rate was 33.3 mm/h (range: 6–93), and the mean CRP was 21 mg/L. Importantly, three patients initially presented with uveitis and were subsequently diagnosed with SLE, while one patient developed uveitis while under azathioprine treatment. Therapeutic management included local corticosteroids, methylprednisolone, hydroxychloroquine, azathioprine, mycophenolate mofetil, and cyclophosphamide.Conclusions Uveitis associated with SLE is a rare but potentially serious manifestation that may cause vision-threatening complications. Our findings highlight that uveitis may, in some cases, precede the diagnosis of SLE, emphasizing the importance of interdisciplinary evaluation.