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Objective The European Agency for Safety and Health at Work (EU-OSHA) is carrying out a 3-year research activity focusing on cardiovascular diseases (CVDs) and Occupational Safety and Health (OSH). It will include several research projects implemented between 2025 and 2027. In this context, the present study consists of an analysis of quantitative data available in the EU on the types, extent and causes of work-related CVDs as well as on sectors, occupations and worker groups at risk. As the study is ongoing, the communication will present the aims, methodology, progress, preliminary findings and expected results.Material and Methods The study will analyse quantitative data on work-related CVDs and occupational accidents related to CVDs collected at EU, Member State, regional, social partner, sectoral level or be implemented by key organisations or actors.Results The analysis will give insights on the types and prevalence of work-related CVDs and occupational accidents related to CVDs, the underlying causes, occupational exposures, and risks as well as on the sectors, occupations and worker groups at risk. It will also seek to improve knowledge on multiple occupational exposures to combined occupational risk factors of work-related CVDs in the workplace. Finally, it will attempt a comparative qualitative analysis of the data provided by the various data systems and identify the data gaps, challenges and needs.Conclusion The study will formulate conclusions and key policy pointers for the implementation of efficient collection systems, for the availability of comprehensive, reliable quality data, and for the effective prevention of work-related CVDs in the EU.