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The prevalence of diabetes is increasing globally. The International Diabetes Federation reported that the number of diabetes cases reached 425 million in 2017, and this is predicted to total 693 million globally by 2045. Most increases in the diabetic patients were type 2 (T2D), supposed to be due to the changes in lifestyle including overeating, obesity, low exercise, and aging. On the other hand, the number of type 1 diabetes (T1D) mainly caused by the autoimmunity against pancreatic β-cells is increasing at 3% every year. The rate of increase of T1D due to autoimmunity cannot explain the increasing level of T1D. Environmental factors including toxins and viruses are also considered to be responsible for the increasing prevalence of T1D.1 2