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A 20-year-old woman was admitted to our hospital with a 1-year history of discovery of splenomegaly as well as a 3-day history of fever, abdominal pain and melena. She has been prone to recurrent upper respiratory tract infections since childhood, and each episode was accompanied by fever and required intravenous antibiotic treatment. At the age of 11, she developed lymphadenopathy, for which no regular treatment or follow-up was conducted. At 16 years old, she suffered from sepsis, which was subsequently resolved. She had a history of allergies to unknown allergens, while her menstrual history was generally normal. Her parents were non-consanguineous.