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The UK Medical Eligibility Criteria for Contraceptive Use (UKMEC) provides evidence-based guidance on the safety of contraceptive methods for individuals with specific medical conditions. The 2025 update began in 2023 with a scoping review, followed by targeted literature reviews and appraisal by a multidisciplinary Guideline Development Group (GDG). This editorial summarises the key revisions introduced in the 2025 UKMEC. 1