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Background and Importance Polypharmacy in elderly trauma patients exposes them to significant risks of adverse drug events (ADEs), drug–drug interactions, and functional decline. This population often receives complex, overlapping therapies for chronic comorbidities and acute injuries. Clinical pharmacist-led medication reviews have proven to optimise therapy, reduce potentially inappropriate medications (PIMs) and improve collaboration between prescribers and pharmacists. However, few data are available in trauma units regarding their direct clinical impact on medication safety.Aim and Objectives The study aimed to assess the impact of pharmacist-led medication reviews on the detection and resolution of PIMs and drug interactions in elderly trauma inpatients. Secondary objectives were to evaluate the acceptance rate of pharmacist recommendations and to measure the change in ADE incidence following pharmacist interventions.Material and Methods A prospective evaluation was conducted over 2 months in 2025, including 72 trauma patients aged ≥ 65 years. Each treatment was reviewed by a clinical pharmacist using STOPP/START criteria and validated drug interaction databases. Medications were classified according to the WHO Anatomical Therapeutic Chemical (ATC) classification system to identify high-risk pharmacological groups. Interventions were discussed with prescribers, and all modifications were recorded. Statistical analysis (descriptive and comparative) was performed using acceptance rate and change in ADE frequency as key outcomes.Results Among 72 patients, 34 (47%) had at least one PIM, and 19 (26%) experienced significant drug interactions. A total of 61 therapeutic recommendations were made by the pharmacist, of which 52 (85%) were accepted and implemented. Following these interventions, the ADE rate decreased by 31% compared with the previous quarter. ATC analysis identified PIM prevalence mainly in C (Cardiovascular system), N (Nervous system), and B (Blood and blood-forming organs) classes.Conclusion and Relevance Pharmacist-led medication review is an effective, low cost approach to optimise prescribing and minimise ADEs in elderly trauma patients. Integration of ATC-based evaluation strengthens detection of high-risk classes. Routine implementation of this clinical service should be encouraged to promote safe pharmacotherapy in geriatric trauma care.References and/or Acknowledgements 1. O’Mahony D, et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44(2):213–8.2. Spinewine A, et al. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet. 2007;370(9582):173–84.Conflict of Interest No conflict of interest